All types of smog decrease visibility and, with the possible exception of ice fog, are irritating to the respiratory system. Statistical studies indicate that smog is a contributor to malignancies of many types. Photochemical smog produces eye irritation and lacrimation and causes severe damage to many types of vegetation, including important crops. Acute effects include an increased mortality rate, especially among persons suffering from respiratory and coronary ailments. Air pollution also has a deleterious effect on works of art (see art conservation and restoration).

Air pollution on a regional scale is in part the result of local air pollution--including that produced by individual sources, such as automobiles--that has spread out to encompass areas of many thousands of square kilometers. Meteorological conditions and landforms can greatly influence air-pollution concentrations at any given place, especially locally and regionally. For example, cities located in bowls or valleys over which atmospheric inversions form and act as imperfect lids are especially likely to suffer from incidences of severe smog. Oxides of sulfur and nitrogen, carried long distances by the atmosphere and then precipitated in solution as acid rain, can cause serious damage to vegetation, waterways, and buildings.